Naslov
Segmental reduction of corpus callosum is correlated with cognitive performance in adolescents with perinatal white matter brain injury

Autori
Čuljat, Marko ; Kostović-Srzentić, Mirna ; Mejaški-Bošnjak, Vlatka ; Kostović, Ivica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Developmental Medicine and Child Neurology - Abstracts 2008 / - , 2008

Skup
20th Annual Meeting of the EACD

Mjesto i datum
Zagreb, Hrvatska, 05.06.2008. - 06.06.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
corpus callosum; cognitive; white matter injury

Sažetak
The aim of this study was analyze in detail the segmental reduction of corpus callosum (CC) and relate it with cognitive performance in adolescent age, in a group of perinatally brain damaged children. Neuropsychological testing, structural magnetic resonance imaging and CC segmentation were performed in a group of 65 children, aged 13-16 years, who suffered hypoxic-ischemic injury and/or hemorrhagic lesions of areas of periventricular crossroads of pathways, as detected by ultrasound. Cognitive assessment included the Wechsler Intelligence Scale for Children (WISC), verbal fluency task and the Rey-Ostterieth Complex Figure Test (ROCFT). The midsagittal section of CC was delineated and segmented into 99 rostrocaudal segments (C1-C99) taking into account the curvature of the CC, which allows a comparison between subjects, regardless of the CC shape. Results of verbal subtests of WISC and verbal fluency task correlated with segments C1-C21, presumptive areas of commissural fibers of prefrontal associative cortical areas, and segments C71-C99, presumptive areas of commissural fibers of associative parietal, occipital and temporal areas. Results of nonverbal subtests correlated with C1-C21 and C41-C99, which involve not only commissural fibers of associative cortical areas, but also of motor and somatosensory areas. Results of ROCFT visuospatial construction task correlated with C41-C96, while the visuospatial memory task of ROCFT was also related to C7-C16. In conclusion, perinatal injury of periventricular crossroads of pathways leads to segmental and general reduction of callosal midsagittal area, which is highly correlated with cognitive results in adolescent age, allowing for a connectivity based explanation of long-term specific neurocognitive deficits.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA