Naslov
IL-1β-511 T/C polymorphism does not contribute to GEP-NET susceptibility

Autori
Cigrovski Berković, Maja ; Zjačić Rotkvić, Vanja ; Kapitanović, Sanja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of Human Genetics, European Human Genetics Conference 2009 / ESHG - Beč : Nature publishing group, 2009, 174-174

Skup
European Human Genetics Conference 2009

Mjesto i datum
Beč, Austrija, 23.05.2009. - 26.05.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
IL-1β ; polymorphisms ; GEP-NET susceptibility

Sažetak
GEP-NETs represent a heterogeneous group of tumors, arising from diffuse endocrine system of gut and pancreas. Tumors are either solitary, or occur as a part of MEN-1 syndrome. The genetic basis of GEP-NETs is still largely unknown, but there is growing evidence that chronic inflammation through proinflammatory cytokines contributes to patients’ susceptibility to acquire tumors. The role of IL-1β in the gastrointestinal tract inflammation and cancerosis has been extensively studied and T allele at -511-IL-1β promotor region was associated with aggravated inflammatory reaction measured through elevated IL-1β serum levels, higher gastric cancer susceptibility and worse prognosis. The aim of our study was to estimate allelic frequency for -511 promotor SNP in IL-1ß gene in patients with GEP-NETs. DNAs obtained from 101 GEP-NET patients and 150 unrelated healthy volunteers were genotyped for the IL-1β-511 SNP using real-time PCR TaqMan® SNP genotyping assays. To compare the frequencies χ 2 test was used and results were significant if p<0.05. Although high expression genotypes (T/C and T/T) and T-allele occurred more frequently among GEP-NET patients (63.37% vs. 56.67% and 38.61% vs. 35% respectively), there were no statistically significant differences in genotypes distribution (p=0.5541), high expression genotypes (p=0.3530) or in the allelic distribution (p=0.4651) between patients and controls. Although important in pathogenesis of gastrointestinal adenocarcinoma, IL-1β seems not to contribute to GEP-NET development.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA