Naslov
Can suicidal risk be disclosed by transcranial sonography (TCS)?

Autori
Budišić, Mislav ; Karlović, D ; Trkanjec, Zlatko ; Lovrenčić Huzjan, Arijana ; Ažman, Dražen ; Strineka, Maja ; Demarin, Vida

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Cerebrovascular Diseases, 27, suppl.5 / Hennerici, M.G. - Basel : Karger Publishers, 2009, 39-40

ISBN
978-3-8055-9157-7

Skup
14th Meeting of the European Society of Neurosonology and Cerebral Hemodynamics

Mjesto i datum
Riga, Latvija, 23.05.2009. - 25.05.2009

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
suicidal risk ; depression ; transcranial ; sonography ; TCS

Sažetak
Aims: Recent TCS studies showed that disruption of echogenic midbrain line corresponding to basal limbic system and raphe nuclei (RN) within might represent functional marker for the development of depression (irrespective of diagnostic category). Also, depression is the most common psychiatric disorder associated with suicidal ideation. Still there is lack of evidence that, at patients with suicidal ideation, TCS might record same RN alteration. Therefore, we initiated this study to test the possibility of TCS to disclose suicidal risk at patients with major depressive disorder (MDD). Methods: Altogether 90 subjects: 30 patients with MDD, 30 patients with MDD who also reported suicidal ideation and 30 healthy controls where studied using TCS. Severity of the disease was measured according to Hamilton Depression Rating Scale (HDRS) and clinical global impression scale (CGI). Examination was performed by standardized semiqvantative protocol. Results: Reduced raphe echogenicity was found in 16 of 30 (53%) of the patients with MDD but only in 6 of 30 (20%) controls. In patients with suicidal ideations that finding was even more pronounced 22 of 30 (73%), with the highest frequency of completely not visible TCS RN finding 20 of 30 (67%). Conclusion: Our result showed that hipoechogenicity of the RN is frequent in patients with MDD. Such finding is rare in healthy subjects ; however, in suicidal patients that finding was even more pronounced. These results suggest that TCS might be a novel neuroimaging method for screening for suicidal patients within the group of the depressed one.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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