Naslov
Prognostic significance of cytochemical analysis of leukemic M2 blasts

Autori
Sučić, Mirna ; Boban, Dubravka ; Marković- Glamočak, Mirjana ; Petrovečki, Mladen ; Marušić, Matko ; Labar, Boris

Izvornik
Medical oncology (0736-0118) 9 (1992), 1; 41-45

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
acute myeloblastic leukemia M2 ; Myeloperoxidase ; Sudan black B ; Acid phosphatase ; Alpha-naphthyl acetate esterase

Sažetak
Cytochemical analysis of leukemic blasts from 46 patients with acute myeloblastic leukemia (acording to the FAB classification) was performed before and after cytostatic therapy, and compared with findings obtained in 20 age- and sex- matched control subjects. Cytochemical findings for myeloperoxidase (MPO), Sudan black B, acid phosphatse and alpha-naphtyl-acetate esterase (ANAE) were related to the achievement of the first complete remission (CR), i.e. data were compared after the patients had been divided into CR and non-CR groups. The analysis clearly showed that high proportion of myeloperoxidase- and, to a lesser extent, Sudan black B- positive blasts before treatment may have constituted a significantly unfavourable prognostic factor.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA