Naslov
Dynamics of distribution of H-3-inulin between the cerebrospinal fluid compartments

Autori
Vladić, Anton ; Klarica, Marijan ; Bulat, Marin

Izvornik
Brain Research (0006-8993) 1248 (2008); 127-135

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cerebrospinal fluid (CSF); 3H-inulin; 3H-inulin distribution; 3H-inulin absorption; cerebral capillaries; fluid mixing

Sažetak
Since the distribution of substances between various cerebrospinal fluid (CSF) compartments is poorly understood, we studied 3H-inulin distribution, over time, after its injection into cisterna magna (CM) or lateral ventricle (LV) or cisterna corporis callosi (CCC) in dogs. After the injection into CM 3H-inulin was well distributed to cisterna basalis (CB), lumbar (LSS) and cortical (CSS) subarachnoid spaces and less distributed to LV. When injected in LV 3H-inulin was well distributed to all CSF compartments. However, after injection into CCC 3H-inulin was mostly localized in CCC and adjacent CSS, while its concentrations were much lower in CM and CB and very low in LSS and LV. Concentrations of 3H-inulin in venous plasma of superior sagittal sinus and arterial plasma were very low and did not differ significantly, while its concentration in urine was very high. In 3H-inulin distribution it seems that two simultaneous processes are relevant: a) the pulsation of CSF with to-and-fro displacement of CSF and its mixing, carrying 3H-inulin in all directions, and b) the passage of 3H-inulin from CSF into nervous parenchyma and its rapid distribution to a huge surface area of capillaries by vessels pulsations. 3H-inulin then slowly diffuses across capillary walls into the bloodstream to be eliminated in the urine.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

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