Naslov
Prenatal development of nitrinergic neurons in the human basal forebrain

Autori
Džaja, Domagoj ; Ažman, Dražen ; Judaš, Miloš

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
6th Forum of European Neuroscience ABSTRACT BOOK / - , 2008, 20-20

Skup
6th FENS Forum

Mjesto i datum
Ženeva, Švicarska, 12.07.2008. - 16.07.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
nitrinergic neurons ; basal forebrain ; development

Sažetak
We present the first evidence on prenatal development of nitrinergic neurons in the human basal forebrain (BF). We used Neurolucida equipment for qualitative and quantitative analysis of dendritic development of BF nitrinergic neurons selectively visualized by NADPH-diaphorase histochemistry at three main periods of their prenatal development: (1) at 15 postconceptional weeks (PCW), when BF afferents temporarily reside in the 'waiting'compartment of the subplate zone (SP) ; (2) at 22 and 26 PCW, when BF afferents relocate from SP to the cortical plate ; and (3) in 13-day-old term newborn. We analyzed 202 neurons from 4 specimens of the Zagreb Neuroembryological Collection. At 15 PCW, nitrinergic BF neurons are already numerous but immature and mostly bipolar. They rapidly differentiate during the midfetal period, so that at 26 PCW several morphological types (bipolar, fusiform, multipolar, triangular, arciform) were clearly recognized. The same types were present in the newborn, when their dendritic domains seemed to attain adult sizes and shapes. In contrast to the adult human BF in which Ellison et al. (J Comp Neurol 260:233, 1987) described only small and medium size nitrinergic neurons, we found that fetal and newborn BF also contains quite large nitrinergic neurons which display morphology typical for magnocellular cholinergic BF neurons. Therefore, we suggest that large cholinergic BF neurons transiently produce NO during prenatal and perinatal period. Supported by Croatian Ministry of Science, Education & Sport grant No. 108- 1081870-1878 (to M. J.)

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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