Naslov
Development of morphological types and dendritic arborization of nitrinergic neurons in the human neostriatum

Autori
Judaš, Miloš ; Sedmak, Goran ; Bene, Raphael

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
6th Forum of European Neuroscience ABSTRACT BOOK / - , 2008

Skup
6th FENS Forum

Mjesto i datum
Ženeva, Švicarska, 12.07.2008. - 16.07.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
nitrinergic neurons; striatum; development

Sažetak
We analyzed development of nitrinergic neostriatal neurons, by using NADPH-diaphorase histochemistry and stereological software “ Neurolucida” , in fetuses aged 15, 19 and 22 postconceptional weeks ; 3 newborns, 12.5 year-old child and 22-year-old young adult (all 8 specimens are the part of the Zagreb Neuroembryological Collection). A key period for growth of dendritic arborizations of striatal nitrinergic neurons is the second half of gestation, with developmental peak during the last trimester. We did not find significant differences in the extent and shape of dendritic arborizations of striatal nitrinergic neurons between newborn, child and adult brain, suggesting that their development ended at or shortly before birth. In the midfetal period, striatal nitrinergic neurons were immature and mostly bipolar, with poorly branched or nonbranched primary dendrites. In contrast, four morphological types of nitrinergic neurons described in adult human neostriatum by Kowall et al. (1987) and Bernacer et al. (2005) were present in newborn. We could not identify all of 12 types of striatal nitrinergic neurons described in the adult human striatum by Johannes et al. (2003) ; however, we noted some new types in the developing brain. When compared to current classifications of striatal nitrinergic neurons in adult human brain, our findings offer the first classification of human neostriatal nitrinergic neurons during prenatal and postnatal development and the first data on period of intensive dendritic growth of these neurons. Our findings are relevant for analysis of development of striatal nitrinergic neurons in non-human mammalian brains (e. g., experimental animal models for studying basal ganglia disorders), for analysis of human developmental brain disorders which affect striatal development, as well as in the neuropathological analysis of basal ganglia disorders. Supported by Croatian Ministry of Science grant No. 108-1081870-1878 (to M. J.)

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA