Naslov
Antitumor activity of new heteropolycyclic substances from the series of benzo-thieno-quinolones and thieno-thienyl-quinolones

Autori
Slade, Neda ; Grdiša, Mira ; Dogan-Koružnjak, Jasna ; Karminski-Zamola, Grace ; Zamola, Branimir ; Pavelić, Krešimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
2nd International Conference on Signal Transduction ICST, Program and Abstracts / - Zagreb, 2000, 115-115

Skup
2nd International Conference on Signal Transduction ICST

Mjesto i datum
Cavtat, Hrvatska, 26.05.2000. - 31.05.2000

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Antitumor activity; benzothieno- dithienoquinolones

Sažetak
A few new condensed heterocyclic quinolones from benzo(b)thieno- and thieno(2, 3-b)thienyl- series were prepared by multistep and photochemical synthesis, with specific substituents in benzene and thiophene nucleus as well as in the quinolone nucleus. All compounds were tested in vitro for their cytoststic activities on human fibroblast cell line WI-38 and on the following malignant human tumor cell lines: cervical carcinoma(HeLa). breast carcinoma(MCF-7), colon carcinoma (CaCo-2), pancreatic carcinoma(MIA PaCa-2), laryngeal carcinoma(Hep-2) and melanoma(HBL).

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA