Pregled bibliografske jedinice broj: 394575
Hydrazinolysis study of phthalimido- and phthalisoimido-penicillin amide derivatives
Hydrazinolysis study of phthalimido- and phthalisoimido-penicillin amide derivatives // ARKIVOC, 2009 (2009), Part 7; 237-246 doi:10.3998/ark.5550190.0010.723 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 394575 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Hydrazinolysis study of phthalimido- and phthalisoimido-penicillin amide derivatives
Autori
Cerić, Helena ; Šindler-Kulyk, Marija
Izvornik
ARKIVOC (1551-7004) 2009
(2009), Part 7;
237-246
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
β-lactam ; dephthaloylation ; hydrazinolysis ; penicillin ; phthaloyl-protection ; thiazolidine
Sažetak
New phthalimido-penicillin amide (6-PhtPABn) and phthalisoimido-penicillin amide (6-isoPhtPABn) were prepared and the susceptibility of their different carbonyl functions toward hydrazine derivatives investigated in order to establish the feasibility of dephthaloylation within penicillin class compounds. Hydrazinolysis of phthalimido-penicillin amide (6-PhtPABn) resulted in dephthaloylation and β -lactam ring opening into thiazolidine derivatives, while in the case of phthalisoimido-penicillin amide (6-isoPhtPABn), the desired amino-penicillin amide (6-APABn) was isolated in low yield.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
MZOS-125-0982933-2926 - Heteropolicikli, strukturne osnove za bioaktivne spojeve. Sinteza i fotokemija (Škorić, Irena, MZOS ) ( CroRIS)
Ustanove:
Pliva-Istraživački institut,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
Uključenost u ostale bibliografske baze podataka::
- CA Search (Chemical Abstracts)
