Pregled bibliografske jedinice broj: 39438
Synthesis of fenoprofen prodrugs
Synthesis of fenoprofen prodrugs // European Journal of Pharmaceutical Sciences, Vol. 11/Suppl. 1 (2000);Abstracts: 6th European Congress of Pharmaceutical Sciences, EUFEPS 2000 / Linden, H. (ur.).
Oxford: Elsevier, 2000. (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 39438 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Synthesis of fenoprofen prodrugs
Autori
Zovko, Marijana ; Zorc, Branka ; Jadrijević-Mladar Takač, Milena
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
European Journal of Pharmaceutical Sciences, Vol. 11/Suppl. 1 (2000);Abstracts: 6th European Congress of Pharmaceutical Sciences, EUFEPS 2000
/ Linden, H. - Oxford : Elsevier, 2000
Skup
6th European Congress of Pharmaceutical Sciences, EUFEPS 2000
Mjesto i datum
Budimpešta, Mađarska, 16.09.2000. - 19.09.2000
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
fenoprofen; prodrug; amides; stirene-maleic copolymer ( SMA)
Sažetak
Fenoprofen (1), a well known analgesic and anti-inflammatory agent was transformed to amide derivatives 4 and 5. Fenoprofen first reacted with 1-benzotriazole carboxylic acid chloride (2) to give benzotriazolide 3 which after aminolysis gave the corresponding amides 4a-i. One of them, 2-aminoethyl amide (4i) reacted with styrene-maleic copolymer (SMA) affording the polymer-drug conjugate 5. In compound 5 fenoprofen is covalently bound by amide linkage, through nontoxic ethylenediamine spacer. The synthesised compounds are potential fenoprofen prodrugs.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
