Pregled bibliografske jedinice broj: 39435
A new route to substituted N-hydroxyurea derivatives
A new route to substituted N-hydroxyurea derivatives // European Journal of Pharmaceutical Sciences, Vol. 11/Suppl. 1 (2000);Abstracts: 6th European Congress of Pharmaceutical Sciences, EUFEPS 2000 / Linden, H. (ur.).
Oxford: Elsevier, 2000. str. S111-S112 (poster, međunarodna recenzija, sažetak, znanstveni)
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Naslov
A new route to substituted N-hydroxyurea derivatives
Autori
Jadrijević-Mladar Takač, Milena ; Butula, Ivan
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
European Journal of Pharmaceutical Sciences, Vol. 11/Suppl. 1 (2000);Abstracts: 6th European Congress of Pharmaceutical Sciences, EUFEPS 2000
/ Linden, H. - Oxford : Elsevier, 2000, S111-S112
Skup
6th European Congress of Pharmaceutical Sciences, EUFEPS 2000
Mjesto i datum
Budimpešta, Mađarska, 16.09.2000. - 19.09.2000
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Substituted N-Hydroxyurea; 1;3;5-triazine-2;4;6-trione derivatives; Synthesis
(Substituted N-Hydroxyurea; 1;3;5-triazine-2;4;6-trione derivatives; Synthesis)
Sažetak
The reaction of (1, Bz = benzyl) with fosgene (i) gave 1,3,5-(tribenzyloxy)biuret (2), whereas with BtCOCl (Bt = benzotriazolyl) (ii) gave 1-(N-benzyloxy)carbamoylbenzotriazole (5). Compounds 2 and 5 were reduced to their corresponding hydroxyl derivatives 3 and 6 (iii).
The 5 and 6 were melted in presence of imidazole to afford 1,3,5-triazine-2,4,6(1H,3H,5H)-triones 7, X = -CON(OBz)CO-, and 8, Y = -CON(OH)CO- (iv).
Compounds 5, 6 or 7 in the reaction with ChNH2 (Ch = cyclohexyl) gave O- and/or N-substituted N-hydroxyureas 9 and 10 (v), whereas 8, due to its acidic properties, rather form cyclohexylamine salt.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
