Naslov
The symmetry of the aortic outflow velocity profile in aortic stenosis: a novel predictor of functional improvement after aortic valve replacement?

Autori
Čikeš, Maja ; Kalinić, Hrvoje ; Herrmann, Sebastian, Lončarić, Sven ; Miličić, Davor ; Čikeš, Ivo ; Sutherland, George R. ; Weidemann, Frank ; Bijnens, Bart

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 7th Congress of the Croatian Cardiac Society with International Participation ; u: Liječnički Vjesnik. Supplement / Miličić, Davor ; Čikeš, Maja - Zagreb : Hrvatski liječnički zbor, 2008, 61-61

Skup
Congress of the Croatian Cardiac Society with International Participation (7 ; 2008)

Mjesto i datum
Opatija, Hrvatska, 16.10.2008. - 19.10.2008

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
aortic stenosis; doppler echocardiography; remodelling

Sažetak
LV outflow Doppler traces in severe aortic stenosis (AS) show higher, often prolonged velocities. Although the pressure gradient measured over a stenotic valve is indicative of stenosis severity, it often does not relate to myocardial function or changes in contractility resulting from myocardial damage. We hypothesize a relation between the shape of the profile of the aortic outflow velocity and myocardial function in AS. 35 patients undergoing aortic valve surgery for severe AS were studied by echocardiography pre- (PRE) and 1 year postoperatively (POST). 29 healthy volunteers served as controls. Ejection fraction (EF), aortic valve area (AVA) and mean aortic gradient (PG mean) were measured while semi &#8211; automated analysis was applied to aortic continuous wave (CW) velocity traces. The asymmetry of the velocity profile (asymm) was quantified as the normalized difference of area under the curve of left and right half of the spectrum so that a lower asymm corresponds to more symmetrical, later peaking flow. A significant correlation was found between asymm PRE and change in EF POST-PRE (r=0.66, P<0.05). No correlations were found between AVA nor PG mean and change in EF POST-PRE (r=0.05, r=0.04 ; P>0.05). Asymm PRE did not correlate significantly with PG mean PRE (r=0.18), while the patients with values of asymm PRE > 0.15 all showed improvement in EF POST-PRE, regardless of PG mean PRE. A symmetrical aortic outflow profile might reflect not only higher grade AS, but seems related to a reduction in LV function and predicts its recovery after surgery with higher confidence than preoperative mean gradient. Semi-automated analysis provides additional clinical information on the functional impact of AS.

Izvorni jezik
Engleski

Znanstvena područja
Računarstvo, Kliničke medicinske znanosti, Informacijske i komunikacijske znanosti

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