Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats

Ilić, Spomenko; Drmić, Domagoj; Žarković, Kamelija; Kolenc, Danijela; Ćorić, Marijana; Brčić, Luka; Kliček, Robert; Radić, Božo; Sever, Marko; Djuzel, Viktor; Ivica, Mihovil; Boban Blagaić, Alenka; Zoričić, Zoran; Anić, Tomislav; Zoričić, Ivan; Džidić, Senka; Seiwerth, Sven; Sikirić, Predrag

doi:10.1016/j.ejphar.2011.05.038

Pregled bibliografske jedinice broj: 393174

Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats

Ilić, Spomenko; Drmić, Domagoj; Žarković, Kamelija; Kolenc, Danijela; Ćorić, Marijana; Brčić, Luka; Kliček, Robert; Radić, Božo; Sever, Marko; Djuzel, Viktor et al.

Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats // European journal of pharmacology, 667 (2011), 1-3; 322-329 doi:10.1016/j.ejphar.2011.05.038 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 393174 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats

Autori
Ilić, Spomenko ; Drmić, Domagoj ; Žarković, Kamelija ; Kolenc, Danijela ; Ćorić, Marijana ; Brčić, Luka ; Kliček, Robert ; Radić, Božo ; Sever, Marko ; Djuzel, Viktor ; Ivica, Mihovil ; Boban Blagaić, Alenka ; Zoričić, Zoran ; Anić, Tomislav ; Zoričić, Ivan ; Džidić, Senka ; Seiwerth, Sven ; Sikirić, Predrag

Izvornik
European journal of pharmacology (0014-2999) 667 (2011), 1-3; 322-329

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
paracetamol ; hepatic encephalopathy ; convulsions ; pentadecapeptide BPC 157 ; rats

Sažetak
We challenged rats with chronic ibuprofen application (0.4g/kg intraperitoneally once daily for 4 weeks) and the stable gastric pentadecapeptide BPC 157 therapy. We evidenced a deleterious circuit not reported in ibuprofen-rats as yet: hepatic encephalopathy, gastric lesions, hepatomegaly, increased AST and ALT serum values, with prolonged sedation/unconsciousness and weight loss. In particular, ibuprofen toxicity exhibited itself as brain edema and cyanosis, particularly in the cerebellum, more so in white than in gray mater, damaged (balonized) red neurons, without any inflammatory reaction, particularly in the cerebral cortex and cerebellar nuclei, less in the hippocampus, dentate nucleus and Purkinje cells. BPC 157 (GEPPPGKPADDAGLV, MW 1419, 10µ ; g, 10ng/kg) was fully effective given as an antidote after ibuprofen: (i) intraperitoneally, immediately after ibuprofen or (ii) in drinking water (0.16 µ ; g, 0.16 ng/ml) until the end of the 4 week-experiment. Thus, apart from its role as an anti-ulcer peptide, efficient in inflammatory bowel disease trials (PL14736) and various wound treatment, with no toxicity reported and which already showed various hepatoprotective effects, either BPC 157 regimen counteracted

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA

Projekti:
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108-1083570-3636 - Učinak BPC 157 na induciranu bilijarnu opstrukciju (Anić, Tomislav, MZOS ) ( CroRIS)
108-1083570-3634 - Genetička istraživanja učinka BPC-157 na mikroorganizmima (Džidić, Senka, MZOS ) ( CroRIS)
108-1083570-3643 - Kvantitativna analiza i prijenos slike u patologiji (Seiwerth, Sven, MZOS ) ( CroRIS)