Naslov
Incidence of nausea and vomiting after laparoscopic gynecological surgery is decreased in luteal phase of the menstrual cycle

Autori
Mraović, Boris ; Šimurina, Tatjana ; Sonicki, Zdenko ; Šerić, Julija ; Markulin, Zorica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The European Anaesthesiology Congress : Euroanesthesia 2009 : Abstracts and Programm ; u: European Journal of Anaesthesiology 26 (2009) (S45) / Pollar, P.J. - London : Delhi : Lippincott Williams and Wilkins, 2009, 9AP3-4

Skup
The European Anaesthesiology Congress

Mjesto i datum
Milano, Italija, 06.06.2009. - 09.06.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
menstrual cycle phase; postoperative nausea and vomiting

Sažetak
Female sex is a well recognized risk factor for postoperative nausea and vomiting (PONV)(1). The data about influence of the phase of menstrual cycle on PONV after gynecological laparoscopy are sparse and controversial (2, 3). We investigated whether the phase of menstrual cycle has influence on the incidence of PONV in women undergoing general anesthesia for gynecological laparoscopy in a prospective, double-blind, observation study. After obtaining IRB approval and informed consents, 111 fertile women, ASA PS I/ II, scheduled for laparoscopic gynecological surgery were assigned into three groups according to the phase of menstrual cycle at the time of anesthesia: F1follicular phase (days 1-8), O2ovulatory phase (9-15) and L3luteal phase (16 to the end). Standardized general anesthesia technique was used (sevoflurane in air/ oxygen) and no PONV prophylaxis. Diclofenac and pethidine was used for pain and metoclopramide for PONV. Data were analyzed using and Kruskal Wallis test. P<0.05 was considered significant. There were no significant differences among groups for age, weight, height, BMI, h/o smoking, h/o motion sickness and h/o PONV. The incidence of PONV was significantly lower in L3 for PONV at 0-24h, for early PONV and early nausea. Rescue antiemetic usage, nausea and pain VAS scores, and perioperative opioid consumption were not different among groups. Table1. F1 (n=34) O2 (n=40) L3 (n=37) p PONV (24h) 12 (35) 15 (38) 5 (14) 0.041* PONV (0-2h) 7 (21) 10 (25) 1 (3) 0.021* PONV (2-24h) 5 (15) 8 (20) 5 (14) 0.713 Nausea (24h) 11 (32) 13 (33) 5 (14) 0.102 Nausea (0-2h) 7 (21) 9 (23) 1 (3) 0.032* Nausea (2-24h) 4 (12) 6 (15) 5 (14) 0.921 POV (24h) 9 (27) 11 (28) 5 (14) 0.274 POV (0-2h) 5 (15) 7 (18) 1 (3) 0.106 POV (2-24h) 4 (12) 5 (13) 5 (14) 0.975 *p<0.05, F1= follicular, O2= ovulatory, L3= luteal phase. Data presented as n (%). The incidence of PONV was lower in women in luteal phase of menstrual cycle at 24h, as well as the incidence of early PONV and early nausea. Further studies with larger groups and hormonal measurements are needed to confirm this finding. Scheduling patients in luteal phase of menstrual cycle could decrease the risk for PONV in gynecologic laparoscopic surgery. References: 1. Gan TJ, et al. Anesth Analg 2007 ; 105:1615-28. 2. Gratz I, et al. Anesth Analg 1996 ; 83:565-9. 3. Sener EB, et al. Gynecol Obstet Invest 2005 ; 59:49-53.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA