Naslov
Comparison of azithromycin and doxycycline in the treatment of erythema migrans

Autori
Baršić, Bruno ; Maretić, Tomislav ; Majerus Ljiljana ; Strugar, Jadranka

Izvornik
Infection (0300-8126) 28 (2000), 3; 153-156

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
lyme; erythema migrans; azythromycin; doxycycline; borrelia

Sažetak
Background: A randomised, multicenter, open clinical trial was undertaken in order to compare the efficacies of azithromycin and doxycycline in the treatment of patients with Lyme disease associated with erythema migrans. Patients and methods: A total of 48 patients were treated orally with azithromycin, 500 mg bid on the first day, followed by 500 mg once daily for the next four days or doxycycline (40 patients) 100 bid for 14 days. Results: Intention-to-treat analysis of clinical efficacy showed no difference between two treatment regimens. Clinical success was observed in 46 (95,8%) azithromycin and 33 (82,5%) doxycycline treated patients, p= 0,0731). Minor symptoms persisted or appeared in the posttreatment period in 2 of 47 azithromycin and 3 of 35 doxycycline treated patients (p=0,646). Major manifestations appeared only in two patients in doxycycline group (p=0,179). There was no difference in the tolerability of the both drugs. Conclusion: Azithromycin (total dose 3 g) is equally effective as standard doxycycline tretament for erythema migrans in adult patients.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA