Pregled bibliografske jedinice broj: 392212
Photochemical degradation of hyperforin
Photochemical degradation of hyperforin // Letters in organic chemistry, 5 (2008), 7; 583-586 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 392212 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Photochemical degradation of hyperforin
Autori
D'Auria, Maurizio ; Emanuele, Lucia ; Racioppi, Rocco
Izvornik
Letters in organic chemistry (1570-1786) 5
(2008), 7;
583-586
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
St-johns-wort; chronic lymphocytic-leukemia; hypericum-perforatum l.; pregnane-x-receptor; constituent hyperforin; cells; drug; inhibition; metabolism; activation
Sažetak
Irradiation of hyperforin in acetonitrile gave a single degradation product with a first order kinetics (k = 3.23 M h(-1)). The degradation product was a 1:1 tautomeric mixture of 2-methyl-3-hydroxy-4-(1-oxo-2-methyl-1-propyl)-1, 5dioxo-6-(3-methyl-1-but-2-enyl)-2-cyclohexene and 2-methyl-1, 3, 5-trioxo-4-(1-hydroxy-2-methyl-1-propylene)-6-(3-methyl-1-but-2-enyl)-cyclohexane. The product can also be obtained through three Norrish II reactions, followed by a fragmentation reaction.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
