Pregled bibliografske jedinice broj: 389882
Macromolecular prodrugs: XII. Primaquine conjugates: Synthesis and preliminary antimalarial evaluation
Macromolecular prodrugs: XII. Primaquine conjugates: Synthesis and preliminary antimalarial evaluation // Acta pharmaceutica, 59 (2009), 107-115 doi:10.2478/v10007-009-0007-x (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 389882 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Macromolecular prodrugs: XII. Primaquine conjugates: Synthesis and preliminary antimalarial evaluation
Autori
Rajić, Zrinka ; Kos, Gabrijela ; Zorc, Branka ; Singh, Prati Pal ; Singh, Savita
Izvornik
Acta pharmaceutica (1330-0075) 59
(2009);
107-115
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
primaquine; polymer-drug conjugate; polyaspartamide; glucosamine; antimalarial activity
Sažetak
New primaquine conjugates 5-7 with glucosamine and two polymers of polyaspartamide type poly  ,  -(N-2-hydroxyethyl-DL-aspartamide) (PHEA) and poly  ,  -(N-3-hydroxypropyl-DL-aspartamide) (PHPA) were synthesized, characterized and screened for their antimalarial activity. The conjugates differed in type of covalent bounding, length of spacer between the polymeric carrier and drug, molecular masses and drug-loading. Blood-schizontocidal activity of the prepared conjugates was tested against Plasmodium berghei infection in Swiss mice. Polymeric conjugates showed better antimalarial activity than the glucosamine conjugate.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Farmacija
POVEZANOST RADA
Projekti:
006-0000000-3216 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Zorc, Branka, MZOS ) ( CroRIS)
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
