Naslov
Expression of FasL molecule in acute and chronic psoriatic plaque

Autori
Prpić Massari, Larisa ; Kaštelan, Marija ; Gruber, Franjo ; Zamolo, Gordana ; Žauhar, Gordana ; Rukavina, Daniel

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
6th Alpe Adria symposium on psoriasis

Mjesto i datum
Bibione, Italija, 07.11.2003. - 08.11.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
FasL molecule; Expression; Acute psoriatic plaque; Chronic psoriatic plaque
(FasL molecule; expression; acute psoriatic plaque; chronic psoriatic plaque)

Sažetak
Psoriasis is autoimmune skin diseas in which keratinocyte proliferation was initiated by T cell infiltration and activation. Among T cells, CD4+ T cell predominance in exacerbated psoriatic plaques and CD8+ T cells in resolutive lesions are demonstrated. Cell mediated cytotoxicity reactions (CMC) are mediated by perforin and granzyme exocytosis or binding of FasL (CD95L) with Fas receptor (CD95) on target cell. CD8+ T lymphocytes and to a certain degree CD4+ T lymphocytes as well as NK cells mediate in CMC. The role of cytolytic Fas/FasL pathway is recognized in psoriasis but still insufficiently defined. The aim of our investigation was to analyze expression of Fas and FasL molecules in the psoriatic skin lesions and highlight a role of cytotoxicity mediated by this pathway in pathophysiology of disease.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA