Naslov
Alopecia areata: Immunohistochemical study in 45 patients in different clinical phases

Autori
Brajac, Ines ; Malnar Dragojević, Daniela ; Tkalčić, Mladenka ; Kaštelan, Marija ; Gruber, Franjo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
11th Congress of European Academy of Dermatovenereology

Mjesto i datum
Prag, Češka Republika, 02.10.2002. - 06.10.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Alopecia areata; Immunohistochemical study; Clinical phases
(alopecia areata; immunohistochemical study; clinical phases)

Sažetak
In 45 patients we analyzed the phenotype of the perifollicular lymphocytic infiltrate in progressive and in stabilized phase of disease. Monoclonal antibodies were used against CD3, CD4, CD8, CD8, IL-2r, and antigens HLA I and II. In specimens from affected skin in progressive phase, CD4+, IL-2r+ and HLA I antigens were widely expressed by the majority of the perifollicular lymphocytes and by the bulbar keratinocytes. CD8+ HLA II antigens were weakly expressed. In the specimens from affected skin in stabilized phase, there were also abundant CD3+ and CD4+ cells. HLA II antigens were unchanged considering progressive phase ; HLA I was weakly expressed than in early lesions ; and CD8+ and IL-2r+ were almost absent. All controls showed very few CD8+ cells scattered throughout the dermis, and few CD4+ cells generally in association with sebaceous glands. HLA I was weakly expressed, and HLA II and IL-2r + were almost absent.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA