Naslov
Genetic thrombophilia and pregnancy complications

Autori
Lenz, Bahrija ; Kvolik, Slavica ; Grahovac, Blaženka.

Izvornik
Clinical Chemistry and Laboratory Medicine

Vrsta, podvrsta
Ostale vrste radova, ostalo

Godina
2008

Ključne riječi
Pregnancy complications; Factor V Leiden; prothrombin 20210G; MTHFR 677C

Sažetak
At least one thrombophilic mutation was observed in 41.6% of women with pregnancy complications vs. to 20.6% of women with normal pregnancies (p=0.003), factor V Leiden was observed in 15.8% cases and 7.8% controls, prothrombin 20210A in 5.9% cases and 2.9% controls and homozygosity for MTHFR 677T, in 19.8% cases and 9.8% controls. Double and triple thrombophilic mutations were detected in 6.9% women with pregnancy complications compared to none in the control group. Women with severe pregnancy complications and related venous thromboembolism have an increased frequency of genetic thrombophilic mutations.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Rad je prikazan kao kongresno priopćenje na 7th International Symposium on Molecular Diagnostics, Medical University of Graz, Austria, May 22 – 24 2008 (A65)i štampan u Clin Chem Lab Med 2008 ; 46(4):45– A66 (Walter de Gruyter • Berlin • New York. DOI 10.1515/CCLM.2008.05)

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