Pregled bibliografske jedinice broj: 388007
Thiolated polyaspartamide is an effective biocompatible coating agent for quantum dots
Thiolated polyaspartamide is an effective biocompatible coating agent for quantum dots // Journal od Drug Delivery Science and Technology, 19 (2009), 2; 139-144 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 388007 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Thiolated polyaspartamide is an effective biocompatible coating agent for quantum dots
Autori
Zorc, Branka ; Lovrić, Jasmina ; Jain, Manasi ; Moquin, Alexandre ; Cho, Sung Ju Cho ; Filipović-Grčić, Jelena
Izvornik
Journal od Drug Delivery Science and Technology (1773-2247) 19
(2009), 2;
139-144
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Thiomers; Quantum dots; Cytotoxicity; Mucoadhesive polymers; Nanomedicine; Nanoparticles; MCF-7; C12; A549P
Sažetak
The objective of this study was to prepare, characterize and test in different cell lines new polymers which could be used as coating materials for nanoparticles. Poly[α , β -(N-2-hydroxyethyl-DL-aspartamide)]-poly[α , β -(N-2-thioethyl-DL-aspartamide)]-copolymers (PHTA) were prepared by aminolysis of poly-DL-(2, 5-dioxo-1, 3-pyrrolidinediyl (polysuccinimide, PSI) with cysteamine and ethanolamine. Results from these studies suggest that PHTA is a biocompatible biopolymer which can stabilize CdTe quantum dots and prevent ROS-induced cytotoxicity in human breast MCF-7 cells and lung carcinoma cells A549. PHTA and similar polymers can be easily functionalized thereby providing suitable nanoparticle surface coating and functionalized nanomedicines.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija, Farmacija
POVEZANOST RADA
Projekti:
006-0061117-1244 - Terapijski nanosustavi (Filipović-Grčić, Jelena, MZOS ) ( CroRIS)
006-0000000-3216 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Zorc, Branka, MZOS ) ( CroRIS)
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
