Naslov
Decidual dendritic cells: enemies or friends of pregnancy

Autori
Laškarin, Gordana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts / Rabatić, Sabina - Zagreb : Hrvatsko imunološko društvo, 2008, 17-17

Skup
2008 Annual meeting of the Croatian Immunological Society

Mjesto i datum
Šibenik, Hrvatska, 09.10.2008. - 12.10.2008

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Dendritic cells; pregnancy

Sažetak
Dendritic cells (DC) have capacity to detect, internalize, process and appropriately respond to many foreign and own antigens with the capacity to orchestrate two qualitatively different types of the immune responses representing by Th1 and Th2 cytokine domination. Although there is no unique concept about the characteristic of distinct DCs subsets which differentially bias NK and T-helper response, it is believed that microbes and the local microenvironment are potent modulators of DCs functions. Recently, tiny populations of immature decidual CD1a+ cells expressing CD14+ molecules were found in close vicinity to endometrial glands. It is possible that glandular epithelial products, like tumor associated glycoprotein-72 (TAG-72) and mucin I (MUC I) tune DCs functions in vivo. Mucin-1 (MUC-1) is drastically reduced in the uterus of many species during the time of embryo implantation. Intense immunostaining of TAG-72 in endometrial epithelial cells was limited to the secretory menstrual interval. We wonder whether mucins are able to shape DC functions at the maternal – fetal interface and whether it could have consequences on initiation and regulation of the local immune response. Decidual CD1a+ cells ware able to bind and internalize both mucins: TAG-72 and MUC I by carbohydrate recognition domains of CD206 and CD209 receptors. TAG-72 efficiently down-regulate CD83 expression and Th1 oriented cytokine/chemokine production, whereas MUC I up-regulated pro-inflammatory decoy receptor expression. TAG-72 reduced IFN- expression in CD1a+ cells, enabling them for settling of decidual T cells toward anti-inflammatory orientation by decreasing IFN- , rather than enhancing IL-4 expression. Down regulation of IL-15 and IL-18 cytokines expression in TAG-72 treated CD1a+ cells, as well as in MUC I treated CD14+ cells could have impact in down-regulation of cytolytic mediators and proliferation of decidual NK cells in the close contact with antigen presenting cells. All these results suggest that mucins provide anti-inflammatory signals which have to be quenched at the narrow peri-implantation period, since mild pro-inflammatory response is necessary for successful implantation and regulation of trophoblast invasion. Acknowledgement: The experiments were financed by Croatian Ministry of Science, Education and Sports Grants No. 0620402-0376, No. 062-620402-0377 and 062-62040-0379.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA