Naslov
Analysis of sister chromatid exchange and micronuclei in peripheral blood lymphocytes of nurses handling cytostatic drugs

Autori
Kašuba, Vilena ; Rozgaj, Ružica ; Garaj-Vrhovac, Vera

Izvornik
Journal of applied toxicology (0260-437X) 19 (1999), 6; 401-404

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
sister chromatid exchange (SCE); micronucleus assay; cytostatic drugs; occupational exposure

Sažetak
The genotoxic effect of occuaptional exposure of 20 nurses who handled cytostatic drugs in medical oncology and haematology units was evaluated by micronucleus and sister chromatide exchange test. The duration of employment in the units and of exposure to cytostatics ranged from 1 to 31 years. The exposed nurses manifested an increase in cells with micronuclei as compared to the control group (P<0.05). Nurses exposed to cytostatic drugs for 20-31 years showed a higher frequency of micronuclei (P<0.05, whereas there was no difference in frequencies between the control group and the group exposed for 1-14 years (P>0.05). The influence of the exposure period proved to be a significant parameter for the micronucleus test. No statistically significant differences were observed in sister chromatid exchange (P>0.05).

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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