Naslov
Patomorphology of renal parenchyma in endemic nephropathy patients with upper urinary tract carcinomas

Autori
Belicza, Mladen ; Demirović, Alma ; Leniček, Tanja ; Tomić, Karla ; Mišić, Maja ; Jakovina, Krunoslav , Jakovina, Tratinčica ; Krušlin, Božo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Acta Medica Salinea / - , 2008, 107-107

Skup
I Congress of Pathologist in B&H, Tuzla, Bosnia and Herzegovina

Mjesto i datum
Tuzla, Bosna i Hercegovina, 13.05.2008. - 15.05.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Patomorphology of renal parenchyma in endemic nephropathy; urinary tract; carcinomas

Sažetak
Introduction: Endemic nephropathy (EN) is associated with an increased frequency of urothelial carcinoma (UC) of upper urinary tract (UUT). Histologically, atrophy of proximal tubules and diffuse cortical fibrosis is the most prominent finding. Aim: Aim of the study was to analyze renal parenchyma of kidney specimens from patients with UC of the UUT from endemic region. Materials and Methods: We analyzed consecutive series of 17 cases (M:F=9:8) of UC of UUT from EN region who underwent nephrectomy in the period from June 2006 to December 2007. These cases were compared with 15 cases (M:F=5:10) of UC of UUT from non-endemic region in Zagreb. In the group of patients from endemic region, 10 (M:F=5:5) patients were from endemic region in Bosnia and Herzegovina, and 7 (M:F=5:2) patients were from endemic region of Slavonski Brod county. Specimens were routinely fixed, embedded in paraffin, cut and stained with haematoxylin and eosin and Mallory trichrome method, and examined by light microscopy. Results: In the group of patients from endemic region 8 patients had grade 2, and 9 had grade 3 of UUT carcinoma. There were 9 cases of UC of ureter and 8 cases of the UC of pyelon. Extensive tubular atrophy was found in 9 cases. In the group of patients from non-endemic region extensive tubular atrophy was found in 2 cases. Prominent interstitial fibrosis characterized 8 cases, compared to 2 cases from non-endemic region. Glomerular sclerosis was observed in 8 cases, compared to 2 cases in non-endemic region. We found signs of thyreoidiziation with prominent interstitial cell infiltration, mostly with mononuclear inflammatory cells in 7 cases compared to 3 cases in non-endemic region. Conclusion: Renal pathomorphology of patients with UUT carcinomas from endemic region differs from patients from non-endemic region. Extensive tubular atrophy and prominent interstitial fibrosis are characteristic findings in patients suffering of UUT carcinomas in endemic region. There were more cases of UC from endemic region from Bosnia and Herzegovina. Due to war and population migration, patients with UC and EN could become patients in other hospitals in Europe. Key words: endemic nephropathy, upper urinary tract carcinomas, patomorphology

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA