Naslov
The Role of Fas/FasL Mechanism in Lichen Planus

Autori
Kaštelan, Marija ; Prpić-Massari, Larisa ; Stojnić-Soša, Liliana ; Brajac, Ines ; Simonić, Edita ; Čabrijan, Leo ; Zamolo, Gordana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
14th Congress of the European Academy of Dermatology and Venereology

Mjesto i datum
London, Ujedinjeno Kraljevstvo, 02.10.2005. - 15.10.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Fas/FasL mechanism; Lichen Planus
(Fas/FasL mechanism; lichen Planus)

Sažetak
A characteristic histological feature of lichen planus is the formation of colloid bodies that represent apoptotic keratinocytes (Sugerman PB, Crit Rev oral biol Med 2002 ; 13:350-365). The apoptotic process mediated by CD8+ cytotoxic T lymphocytes and NK cells mainly involves two distinct pathways, perforin/granzyme and Fas/FasL pathway (Podack ER, J Leukoc Biol 1995 ; 57:548-552). In the present study we have investigated the FasL expression and distribution in the epidermis and dermis of lesional and non-lesional lichen planus skin. Skin biopsy specimens from lesional and non-lesional skin of 10 patients with lichen planus and 8 healthy persons were analysed by immunohistochemistry using biotin-streptavidin-peroxidase method. Statistics were performed using Kolmogorov-Smirnov test to verify the normal distribution of variables and subsequently by Student's t-test. The significant differences in the expression of some lymphocyte subsets, particularly of CD4+ and CD8+ phenotype, were found between lichen planus lesions, non-lesional and healthy skin. The expression of FasL was significantly higher in the lesional compared with non-lesional skin. In conclusion, the accumulation of FasL-positive cells in the lichen planus lesions suggest an active role of Fas/FasL apoptotic pathway in the development of lichen planus.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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