Naslov
Polymorphism of HLA-DQ alleles in Croatian patients with psoriasis

Autori
Kaštelan, Marija ; Gruber, Franjo ; Čečuk-Jeličić, Esma ; Grubić, Zorana ; Prpić Massari, Larisa ; Simonić, Edita ; Kaštelan, Andrija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
12th Congress of the European Academy of Dermatology and Venereology

Mjesto i datum
Barcelona, Španjolska, 15.10.2003. - 18.10.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Polymorphism; HLA-DQ alleles; Croatian patients; Psoriasis
(polymorphism; HLA-DQ alleles; Croatian patients; psoriasis)

Sažetak
In this study, we have analysed the distribution of HLA- DQ alleles in type I and type II Croatian psoriatics by hibridization with specific oligonucleotide probes. Type I psoriasis showed significant association with DQA1*0201 (p 0.00001 ; RR=6.12), DQB1*0201 (p=0.0006 ; RR=3.29) and DQB1*0303 (p=0.0008 ; RR=7.51) alleles. A negative correlation with type I disease was observed for DQA1*0102 allele (p=0.002 ; RR=0.26). Patients with type II psoriasis did not show association with any HLA-DQ alleles. In conclusion, DQA1*0201, DQB1*0201 and DQB1*0303 alleles bear a significant risk for developing type I psoriasis in Croatian population.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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