Naslov
Type I psoriasis is associated with CW*0602-B57-DRB1*0701-DQA1*0201-DQB1*0201 extended haplotype in the Croatian population

Autori
Kaštelan, Marija ; Čečuk, Esma ; Grubić, Zorana ; Gruber, Franjo ; Brajac, Ines ; Prpić-Massari, Larisa ; Kaštelan, Andrija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
JEADV / - , 2002

Skup
10th Congress of European Academy of Dermatology and Venereology

Mjesto i datum
Prag, Češka Republika, 02.10.2002. - 06.10.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Type I psoriasis; CW*0602-B57-DRB1*0701-DQA1*0201-DQB1*0201 haplotype; Croatian population
(type I psoriasis; CW*0602-B57-DRB1*0701-DQA1*0201-DQB1*0201 haplotype; Croatian population)

Sažetak
The inheritance of psoriasis is polygenic. One locus is with certainity located within the 6p chromosome MHC region. Due to linkage disequilibrium in MHC region, Cw6 allele is associated with B57, DRB1*0701, DQA1*0201 and DQB1*0201 or DQB1*0303 alleles, forming the Caucasian extended haplotype EH-57.1 named according to the B allele. We therefore analyzed the distribution of Caucasian extended haplotype in Croatian patients with psoriasis by hibridization with specific oligonucleotides. Type I psoriasis (early onset, positive family history) showed significant association with DRB1*0701 (p 0.00001), DQA1*0201 (p 0.00001), DQB1*0201 (p=0.0006) and DQB1*0303 alleles (p=0.0008). Patients with type II psoriasis (late onset, no family history) did not show association with any class II alleles. The Caucasian extended haplotype Cw*0602-B57-DRB1*0701-DQA1*0201-DQB1*0201 was with significantly higher frequency present in type I patients (p 0.00001 ; RR=7.72). This haplotype did not appear at all in type II psoriatics. Our results show that type I but not type II psoriasis is associated with Cw*0602-B57-DRB1*0701-DQA1*0201-DQB1*0201 extended haplotype in Croatian population.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA