Naslov
Perforin expression is increased in the psoriatic lesions

Autori
Kaštelan, Marija ; Prpić Masarri, Larisa ; Zamolo, Gordana ; Žauhar, Gordana ; Čoklo, Miran ; Gruber, Franjo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Congress on Psoriasis : abstracts ; u: Journal of the European Academy of Dermatology and Venereology / - , 2004, 811-811

Skup
European Congress on Psoriasis

Mjesto i datum
Pariz, Francuska, 21.10.2004. - 24.10.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
psoriasis; NK cells; perforin

Sažetak
The role of cell cytotoxicity mediated by cytotoxic CD8+ T lymphocytes and NK cells in the pathogenesis of psoriasis is still not clear. Cytotoxic T and NK cells mediate cytotoxic reactions mainly by perforin/granzyme and Fas/FasL pathway. Objective was to investigate the expression of perforin molecule, T and NK cells in the psoriatic lesions. Skin biopsy specimens from lesional and non-lesional skin of 11 patients with chronic plaque psoriasis and 8 healthy persons were analysed by immunohistochemistry. Significant increase in whole T cell population, particularly in CD4+ and CD8+ cells were observed in the lesional epidermis and dermis compared with non-lesional (p<0.001)and healthy control (p<0.01). The expression of CD16+ NK cells was significantly lower in lesions compared with healthy skin (p<0.05). Perforin expression was significantly increased in the epidermis of psoriatic lesions (p<0.01). Our data clearly showed the accumulation of CD4+ and CD8+ T cells in psoriatic lesions suggesting a functional interaction of both subsets in creating and maintaining the psoriatic plaque. Increased perforin expression in the epidermis of psoriatic lesions suggest a potential role of this cytolytic pathway in the development of psoriatic plaque.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA