Naslov
Intravenous short-term infusion of high-dose streptokinase in evolving myocardial infarction

Autori
Marinović, Đuro ; Radić-Rupčić, Ana ; Mavrić, Žarko ; Zaputović, Luka ; Roje, Josip

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Fibrinolysis / - , 1986, 347-347

Skup
Eighth International Congress on Fibrinolysis

Mjesto i datum
Beč, Austrija, 08.1986

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Evolving myocardial infarction; Streptokinase; high-dose

Sažetak
The most effective way to limit myocardial necrosis is an early recanalisation of occluded coronary artery. Percutaneous transluminal coronary recanalisation or chemical intracoronary streptokinase (STK) infusion is a first line treatment with a success rate of 65 to 90%. The aim of this study was to evaluate wether intravenous short-therm infusion of high-dose STK could produce similare results. A consecutive series of 42 patients with ECG evidence of acute myocardial infarction and continuous chest pain unresponsive to sublingval nitroglycerin, but less than 6 hours in duration were treated. In all patients 106 IU of STK in 200 ml of saline were infused within 30 minutes. With this protocol the primary success rate was 69%. In 3 patients reocclusion occured within the hospital stay. No serious side-effects were occured. One patient died due to myocardial rupture. As previously reported, this results confirm that intravenous STK may be as effective as intracoronary STK, but expeditious initiation is a crucial determinant for early recanalisation and salvage of myocardium.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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