Naslov
Antimicrobial utilisation and bacterial resistance in Croatian hospitals

Autori
Vlahović-Palčevski, Vera ; Morović, Miro ; Betica Radić, LJiljana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the VII world conference on clinical pharmacology and therapeutics IUPHAR-Division of Clinical Pharmacology & 4th congress of the European Association for Clinical Pharmacology and Therapeutics ; u: British Journal of Clinical Pharmacology 49 (2000) S1 / Velo, G. ; Perucca, E. - Glasgow : Wiley-Blackwell, 2000, 95-95

ISBN
0-632-05858-7

Skup
World conference on clinical pharmacology and therapeutics IUPHAR-Division of Clinical Pharmacology (7 ; 2000) ; Congress of the European Association for Clinical Pharmacology and Therapeutics (4 ; 2000)

Mjesto i datum
Firenca, Italija, 15.07.2000. - 20.07.2000

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
antimicrobial utilisation; bacterial resistance; hospital

Sažetak
It has been generally recognized that the prevalence of bacterial resistance among bacteria is an unavoidable consequence of antibiotic use and is positively linked to the overall use of antibacterial drugs. The purpose of this study was to investigate the extent of antimicrobial usage and to evaluate the antimicrobial resistance at three different hospital settings in Croatia: a clinical hospital, a general hospital and a specialized clinic for infectious diseases. In this survey the antimicrobial drug consumption and antimicrobial susceptibility test results were analyzed for the first 6 months of 1997 in three different hospitals in Croatia: the University Hospital Center (UHC), Rijeka, the Clinic for Infectious Diseases Dr Fran Mihaljevic', Zagreb and the Dubrovnik General Hospital. The data were collected from corresponding hospital pharmacy records and microbiology laboratories. Antimicrobial drug utilization was expressed in number of defined daily doses (DDDs) per 100 bed days. High antimicrobial utilization and high resistance rates were found in all three hospitals. At the Clinic for Infectious Diseases, the most frequently used antimicrobials where those of narrow spectrum while at the UHC Rijeka and the Dubrovnik General Hospital the broad spectrum antimicrobials were mostly used. The highest antimicrobial consumption was noted at the Susak locality of the UHC, Rijeka, where the highest resistance rates of bacteria to antimicrobials were also found. Results of this observational study indicate that attempts should be made to reduce the influence of factors that may lead to emergent resistance. The most effective approach to the prevention of transmission of multidrug-resistant pathogens is preventing the initial emergence of resistance. A rational and strict antibiotic policy is thus of great importance for the optimal use of these agents.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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