Naslov
Azithromycin compared with minocycline in the treatment of acne comedonica and papulo-pustulosa

Autori
Gruber, Franjo ; Grubišić-Greblo, Hanija ; Kaštelan, Marija ; Brajac, Ines ; Lenković, Maja ; Zamolo, Gordana

Izvornik
Journal of Chemotherapy (1120-009X) 10 (1998), 6; 469-473

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Azithromycin; Minocycline; Treatment; Acne comedonica; Acne papulo-pustulosa
(azithromycin; minocycline; treatment; acne comedonica; acne papulo-pustulosa)

Sažetak
This open study was conducted in 72 outpatients with acne vulgaris, to compare the clinical efficacy and tolerability of azithromycin and minocycline. Azithromycin was administered as a single oral dose (500 mg/day) for 4 days in four cycles every 10 days and minocycline was administered 100 mg daily for 6 weeks. Improvement was assessed 6 weeks after initiation of treatment with a four-graded scale. A satisfactory clinical response was observed in 75.8% of the patients treated with azithromycin and in 70.5% of those treated with minocycline. There were no significant differences between these two acne treatments in terms of reduction of the number of lesions (p> 0.05). Both agents were well tolerated and mild side effects were reported in 10.3% of azithromycin and 11.7% of minocycline treated patients. We conclude that azithromycin is at least as clinically effective and well tolerated as minocycline as treatment of facial comedonic and papulopustular acne.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA