Naslov
Multiplicity and Global Parametric Sensitivity of Structured Biological Models

Autori
Tušek, Ana ; Kurtanjek, Želimir

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Proceedings of the ITI 2008, 30th International Conference on Information Technology Interfaces / Lužar-Stiffler, Vesna ; Hljuz Dobrić, Vesna ; Bekić , Zoran - Zagreb : Sveučilišni računski centar Sveučilišta u Zagrebu (Srce), 2008, 797-801

ISBN
978-953-7138-13-4

Skup
30th International Conference on Information Technology Interfaces

Mjesto i datum
Cavtat, Hrvatska, 23.06.2008. - 26.06.2008

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
structured chemostat; PSS; multiplicity; FAST sensitivity

Sažetak
For a paradigmatic biologically structured model multiplicity and global parameter sensitivity of a chemostat are investigated. The modeling assumptions are bisubstrate growth limitation by carbon and nitrogen sources, presence of two essential intracellular compartments, active protein synthesis system (PSS) and inactive genetic compartment. Variance based global sensitivity of the kinetic parameters is evaluated by the Extended Fourier Amplitude Sensitivity Test (FAST). Computer simulations reveal that multiplicity can be induced by carbon source product synthesis inhibition. Results of the FAST analysis show dominant sensitivity on the maximum specific rate coefficients for assimilation of carbon and synthesis of PSS compartment.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

POVEZANOST RADA