Naslov
Cognitive function disorders in complex partial epilepsy

Autori
Šepić Grahovac, Dubravka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
3. hrvatski neurološki kongres : knjiga sažetaka ; u: Neurologia Croatica 50 2011) (S4) / Božićević, D. - Zagreb : Hrvatsko neurološko društvo, 2001, 57-57

Skup
Hrvatski neurološki kongres (3 ; 2001)

Mjesto i datum
Rijeka, Hrvatska, 10.10.2001. - 13.10.2001

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
epilepsy; cognitive function

Sažetak
Epilepsy is a symptom of ictal and interictal brain dysfunction, and the possibility that cognitive impairment develops as a secondary symptom is thus obvious. The consequences of epilepsy are often as important as the epilepsy itself. Impairment of cognitive abilities and decline of intellectual function in epilepsy have been commented on for more than a century. In 1961., Gowers described “ epileptic dementia” as a consequence of the pathologic sequels of seizures. In recent years, factors underlying such cognitive impairments have been subjected to a considerable amount of research. Several investigators have noted that patients with symptomatic epilepsy are more likely to have impairment intellect that those with idiopathic epilepsy. The etiologic factors of epilepsy, seizure type and age onset, seizure frequency, number of frequencies, number of seizures during the life time, an effects of antiepileptic drugs have emerged as important risk factors for the development of cognitive disorders in epileptic patients. Patients with partial complex epilepsy my show impaired memory performance, particularly if seizures are frequent and have an early-age onset. Some others found a subgroup of people with temporal lobe epilepsy existing from an early age, with apparent deterioration after puberty. In patients with newly diagnosed complex partial epilepsy, the hippocampal damage is associated with memory impairment, and some recent data support the idea that the hippocampal damage my be exacerbated by recurrent seizures. These findings suggest that neuroprotection should possibly be considered one of the goals in the treatment of patients, who are at risk of seizure-induced neuronal damage and functional impairment, such as those with drug refractory seizures of temporal lobe. The patients with complex partial seizures very often have cognitive problems that my range from severe cognitive deficit such as poor memory through reduced attention capacity and mental slowing. Sometimes, transient cognitive impairment my be associated with sub clinical seizure discharges and can be demonstrated by EEG monitoring. The importance of the cognitive effects of antiepileptic drugs is greater than has been recognized.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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