Naslov
A retrospective study of 81 patients treated with valproate, valpromide and substained-release valproate

Autori
Cvitanović-Šojat, Ljerka ; Mucić-Pucić, Branka ; Šepić Grahovac, Dubravka ; Hajnzić, Tomislav-Franjo ; Mataija, Marina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts / - Bielefeld : Bethel - Cleveland Clinic, 1999

Skup
10th International Bethel-Cleveland Clinic Epilepsy Symposium

Mjesto i datum
Bielefeld, Njemačka, 14.04.1999. - 18.04.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Epilepsy; Sodium valproate; Valpromide; Substained-release valproate

Sažetak
A retrospective study of 81 patients (PTS) treated with sodium valproate (VPA, Na di-n-propylacetat, Apilepsin) was done. All children had been using VPA as monotherapy or add-on therapy for at least 6 months to five years. The daily dosage was 300 to 1200 mg. Between 74 PTS receiving enteric-coated tablets, aged 3 to 16 years, 52.7% had primary generalized epilepsy and 47, 3% had complex partial seizures that did or did not secondary generalize. Because of the cost of VPA enteric-coated tablets, during 1991/92 in 69 PTS valpromide (VPD, diropylacetamide, Diprozin) was administrated and was free of charge. In 5 schoolchildren sustained-release VPA (SR-VPA, Depakine CR, Orfiril RT) was administrated and paid by the parents. Our retrospective study of 74 PTS led to the following conclusions: PTS with VPA formulation could immediately change to the same daily dosage of VPD or SR-VPA without loss of seizure control. After the change of VPA formulation side effects was not seen. Valproate plasma levels were the same after the administration of VPD and SR-VPA. There was no change in the plasma levels of the other antiepileptic drugs in patients receiving polytherapy. The advantage of SR-VPA is the administration of a single evening dose, but this form is not available in Croatia.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA