Naslov
New trends in the immunopathogenesis of psoriasis

Autori
Kaštelan, Marija ; Prpić Massari, Larisa ; Pašić, Aida ; Gruber, Franjo

Izvornik
Acta dermatovenerologica Croatica (1330-027X) 12 (2004); 26-29

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, stručni

Ključne riječi
Cytokines; Immunopathogenesis; Keratinocytes; Psoriasis; T lymphocytes
(cytokines; immunopathogenesis; keratinocytes; psoriasis; T lymphocytes)

Sažetak
Psoriasis is a chronic hypeproliferative inflam matory skin disease characterized by abnormal keratinocyte hyperproliferation and differentiation, intraepidermal accumulation of neutrophil granulocytes, and dermal inflammatory infiltrate that mostly consists of T-cells. Today, psoriasis is definitely recognized as a T-cell-mediated in flammatory disease. Infiltration of T-cells seems to be the primary event that precedes the keratinocyte hyperproliferation. It is suggested that systemic lymphocyte activation is followed by the local accumulation of specific CD4+ T-cells and subsequently by the activation of intradermal CD8+ T- cells. So far, it seems that CD4+ T-cells create an appropriate type-1 cytokine environment for CD8+ T-cells activation that eventually trigger the psoriatic cascade. Thus, T-cells are responsible for initiation and maintenance of psoriasis. The precise mechanism how activated T-cells trigger psoriasis is yet unknown. However, it seems that the specific immune reaction to aputative antigen, mediated by T-cells leads to creation of psoriatic lesions. The immune reaction constantly driven by bacterial superantigens or epidermal self-antigens eventually leads to development of psoriatic lesions. The psoriatic process is a dynamic process that includes interaction be tween Th1 and Tc1-cells as well as between T-cells and keratinocytes. The better understanding of the immunopathogenesis of psoriasis would allow for development of specific T-cell-targeted and/or cytokine targeted new therapies.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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