Naslov
Proliferating cell nuclear antigen (PCNA) as a prognostic factor for colorectal cancer

Autori
Kovač, Dražen ; Rubinić, Milivoj ; Krašević, Maja ; Križanac, Šimun ; Petrovečki, Mladen ; Štimac, Davor ; Melato, M.

Izvornik
Anticancer research (0250-7005) 15 (1995), 5; 2301-2302

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
PCNA ; Cell proliferation ; Colorectal cancer

Sažetak
PCNA (proliferating cell nuclear antigen) is a cell cycle related protein that is maximally elevated in late G1 and S-phase of proliferating cells. 114 biopsy specimens of colorectal cancer were immunolabeled with PC 10 which specifically recognizes PCNA ; Dukes' staging and histological grading were estimated for each case. All patients were followed-up for at least 60 months or to death. All data were analysed by the computer program NCSS (Number Cruncher Statistical System). According to the results, PCNA-index may be considered an independent prognostic factor for colorectal cancer ; it may also be helpful in supporting the therapeutic strategies based only on Dukes' stage.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA