Naslov
Acquired factor V inhibitor: A case report

Autori
Vukelić-Damijani, Nada ; Balen, Sanja ; Načinović, Antica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Vox Sanguinis Vol. 89 Supplement 1 / Abstracts / Alice Maniatis, PhD, Athens Greece ; Irene Kontopoulou-Griva, MD, Athens, Greece ; Paul Strengers, MD, Amsterdam, the Netherlands - Atena : Basil Blackwell, 2005, 195-195

Skup
XVth Regional Congress of the International Society of Blood Transfusion, Europe, Athens, Greece 2-6 July, 2005

Mjesto i datum
Atena, Grčka, 02.07.2005. - 06.07.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Acquired factor V inhibitor

Sažetak
Acquired factor V inhibitor is extremely rare and is associated with diverse clinical symptomatology that varies from asymptomatic forms of the disease to very severe hemorrhagic episodes with a potentially lethal outcome. It may occur spontaneously or as a result of various clinical conditions. A 50-year-old man was admitted to our hospital with a diagnosis of left-sided periscrotal abscess and scheduled for an incision procedure. During the routine preoperative procedure screening coagulation tests showed pathologic values: APTT 41s, PT 35%, fibrinogen 2, 8g/l, FV 15% (other factors were in normal range), platelet count 189 x10/9/L. Factor V inhibitor was detected by a modified Bethesda assay. The assay showed a low level of inhibitor of about 1.30 Bethesda units (BU). The patient's medical history showed no major morbidity except appendectomy performed 22 years ago. The patient was prepared for operative procedure, with preventive preoperative administration of fresh frozen plasma (FFP) in a dose of 15 mg/kg ( 1500 ml). Upon FFP transfusion, repeated determination of the factor V plasma was unchanged from the initial finding (15%), indicating a failure of therapeutic response. As the measured level of factor V activity was at the borderline hemostatic level, and the operative procedure was not associated with a high risk of hemorrhage, the patient underwent abscess incision. The procedure and postoperative course were uneventful and without major hemorrhage. Laboratory testing for the possible systemic autoimmune disorder produced normal findings. Control examination performed two years later revealed no major clinical or laboratory variation, while a low factor V level persisted (17%) along with the presence of factor V inhibitor at a level of 1.15 BU.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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