Naslov
Immunologic activity in patients with Morbus Basedow and Hashimoto thyreoiditis

Autori
Crnčević-Orlić, Željka ; Zaputović, Luka ; Rukavina, Danijel

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 1st Alps-Adria Immunology and Allergology Meeting ; u: Periodicum Biologorum. Supplement 92 (1990) (S) / - , 1990, 65-65

Skup
1. Alps-Adria Immunology and Allergology Meeting

Mjesto i datum
Opatija, Hrvatska, 14.10.1990. - 17.10.1990

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Basedow hyperthyroidism; Hashimoto thyroiditis; immunological abnormalities; thyrotoxicosis

Sažetak
Basedow hyperthyroidism and Hashimoto thyroiditis are organ specific autoimmune diseases. We intended to evaluate wich immunological abnormalities could be helpful in predicting a relapse of thyrotoxicosis. We studied 70 patients and 30 healthy patients who were a control group. Diagnosis were made on the base of clinical signs, scanes of the thyroid and hormon analyses. Lymphocite population was determined by rosette techniques (direct and indirect) and by indirect immunofluorescent technique. Genetic predisponition was shown by presence of HLA antigens. A significant increase in B and T lymphocytes is noticed during the active phase of both diseases. We conclude that the occurance of the disturbed ratio of T lymphocyte subpopulations during remission of the disease and presence of HLA B8, DR3 or DR5 fenotip can be a prognostic sign of a quick relapse and a significant help in predicting further therapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA