Naslov
Cellular Target Genes of Epstein-Barr Virus Nuclear Antigen 2

Autori
Maier, Sabine ; Staffler, Gabriele ; Hartmann, Andrea ; Höck, Julia ; Henning, Karen ; Grabušić, Kristina ; Mailhamme, Reinhard ; Hoffmann, Reinhard ; Wilmanns, Matthias ; Lang, Roland ; Mages, Jörg ; Kempkes, Bettina

Izvornik
Journal of Virology (0022-538X) 80 (2006), 19; 9761-9771

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Epstein-Barr virus; nuclear antigen 2; B cells; transformation

Sažetak
Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA-2) is a key determinant in the EBV-driven B-cell growth transformation process. By activating an array of viral and cellular target genes, EBNA-2 initiates a cascade of events which ultimately cause cell cycle entry and the proliferation of the infected B cell. In order to identify cellular target genes that respond to EBNA-2 in the absence of other viral factors, we have performed a comprehensive search for EBNA-2 target genes in two EBV-negative B-cell lines. This screen identified 311 EBNA-2-induced and 239 EBNA-2-repressed genes that were significantly regulated in either one or both cell lines. The activation of most of these genes had not previously been attributed to EBNA-2 function and will be relevant for the identification of EBNA-2-specific contributions to EBV-associated malignancies. The diverse spectrum of EBNA-2 target genes described in this study reflects the broad spectrum of EBNA-2 functions involved in virus-host interactions, including cell signaling molecules, adapters, genes involved in cell cycle regulation, and chemokines.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA