Naslov
Predicting sentinel lymph node metastases in infiltrating breast carcinoma with vascular invasion

Autori
Jonjić, Nives ; Mustać, Elvira ; Dekanić, Andrea ; Marijić, B. ; Gaspar, B. ; Kolić, I. ; Čoklo, Miran ; Sasso, Franco

Izvornik
International journal of surgical pathology (1066-8969) 14 (2006), 4; 306-311

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
breast neoplasm ; sentinel lymph node ; lymphovascular invasion

Sažetak
Sentinel lymph node and clinically negative axillary node status was compared with well-known clinicopathological characteristics such as tumor size, histologic and nuclear grade, lymphovascular invasion, steroid receptor, and HER-2 status in patients with breast cancer (pT1 and pT2). Positive sentinel lymph nodes were found in 29 of 100 patients: 19 with metastases detected by hematoxylin and eosin staining and 10 with micrometastases confirmed by immunohistochemistry with cytokeratin. Positive sentinel lymph nodes were present in larger carcinomas (P < 0.03), more frequently in tumors with negative PR status (P < 0.037) and evident lymphovascular invasion (P < 0.002). Lymphovascular invasion was also associated with breast cancer of higher histologic (P = 0.011) and nuclear grade (P = 0.039). Tumor size and the presence of lymphovascular invasion were found to be significant predictors of pathologically positive sentinel lymph node in T1 and T2.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA