Naslov
Nasal challenge with histamine decreases nonspecific bronchial reactivity in workers exposed to respiratory irritants

Autori
Godnić-Cvar, Jasminka ; Somogyi-Žalud, Emese ; Plavec, Davor

Izvornik
American journal of industrial medicine (0271-3586) 35 (1999), 4; 420-425

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
occupational; irritants; bronchial provocation; nonspecific bronchial responsiveness; nasal provocation; nasal nonspecific responsiveness; histamine

Sažetak
Background: A link ("naso-bronchial reflex") between nasal and bronchial reactivity seems to exist. The effect of nonspecific nasal challenge (standing for the exposure to irritative stimuli at the workplace) on lung function indices and nonspecific bronchial reactivity is not known. Methods: In 80 healthy workers (age: 36.0 +/- 8.6 years) continuously exposed to acceptable levels of different respiratory irritants (for more than 2 years) nasal challenge was performed by spraying doubling concentrations of histamine (0.0625-16.0 mg/mL, doses of histamine: 7.8 mu g-2.08 mg) into each nostril. Before and immediately after nasal challenge spirometry and the bronchoprovocation test with histamine (0.5-128 mg/mL) was performed Results: Although nasal challenge with histamine had not reduced airway caliber (before nasal challenge vs, following nasal challenge: FEV1 3.8 +/- 0.8 vs. 3.7 +/- 0.8 L, and MEF50 4.3 +/- 1.4 vs. 4.3 +/- 1.4 L/s, mean +/- SD, respectively), it had significantly reduced nonspecific bronchial reactivity in 30.2% of the irritant-exposed subjects. Conclusions: Nasal challenge with histamine decreases nonspecific bronchial reactivity in workers occupationally exposed to respiratory irritants. Thus, a methodological implication would be that these two tests should not be performed consecutively in less than 2 hr in the same subjects.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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