Naslov
The role of antibodies to mutated citrulinated vimentin (anti-MCV) in juvenile idiopathic arthritis patients

Autori
Tešija Kuna, Andrea ; Žirović, Marijana ; Šimundić Ana-Maria ; Topić, Elizabeta ; Harjaček, Miroslav ; Lamot, Lovro

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
6th international congress on autoimmunity - CD abstracts / Shoenfeld, Yehuda - Ženeva : Kenes Group, 2008, 629-629

Skup
6th international congress on autoimmunity

Mjesto i datum
Porto, Portugal, 10.09.2008. - 14.09.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
anti-MCV antibodies; anti-CCP antibodies; juvenile idiopathic arthritis

Sažetak
Anti-MCV antibodies (Ab) have high sensitivity and prognostic value in patients with RA. We attempt to correlate positive anti-MCV Ab in different subtypes of JIA patients with six core outcome variables. Anti-MCV Ab and Anti-CCP Ab were tested by ELISA (Orgentec, Germany) in sera from 57 JIA, and 14 control patients (12 patients with SLE, 1 with MCTD and 1 with synovial cyst). (16 boys, 41 girls), The mean age was 11, 2 years (range 2, 5– 18, 0), and mean disease duration was 3, 4 years (SD ± ; 2.9). Cut off value ≥ 20 U/mL was considered positive. Positive anti-MCV Ab were detected in only 3/58 (5, 2%) JIA patients, and were significantly elevated in two RF positive polyartritis patients, and slightly elevated in 1/19 (5, 3%) patients with enthesitis-related arthritis (ErA). Among all patients, anti-CCP Ab were positive only in one anti-MCV positive polyarticular JIA patient. Anti-MCV and RF positivity correlated statistically (r = 0, 504, P = 0, 028) in ErA, while no association between anti-MCV Ab and six core outcome variables was observed in this, or other JIA subtypes. Unexpectedly, anti-MCV was detected in 3/12 (25%) SLE patients (2 low positive and 1 significantly positive), and in 1 patient with MCTD. All of these patients were both RF and anti-CCP negative. In contrast to RA, anti-MCV antibodies are not specific for JIA. However, within JIA patients, significantly elevated levels are almost exclusively found in two RF positive, polyarticular patients.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA