Naslov
Platelet serotonin level in rats is under genetic control

Autori
Jernej, Branimir ; Čičin-Šain, Lipa

Izvornik
Psychiatry research (0165-1781) 32 (1990), 2; 167-174

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
platelet serotonin ; selective breeding ; trait characteristic ; genetic control ; hyperserotonemia

Sažetak
It has recently been shown that platelet serotonin (5-hydroxytryptamine, 5HT) levels (PSL) in Wistar rats represent an individually stable biological parameter (neither subject to periodic oscillations nor markedly influenced by sex and age) that shows a unimodal frequency distribution within the population (range: 1.2-2.2 μ g 5HT/mg platelet protein). To investigate the genetic background of PSL, selective breeding for the extreme values of this trait was performed. In the fourth generation, two discrete sublines of animals (statistically different from the unselected population) with constitutionally high or low PSL could be discerned: one with congenitally low PSL (1.1-1.6 μ g 5HT/mg platelet protein ; approximately normal distribution) and the other with congenitally high PSL (1.6-2.9 μ g 5HT/mg platelet protein ; irregular distribution). No difference in the pattern of inheritance between sexes could be discerned. The results demonstrated a marked heritable component underlying the expression of individual values of PSL in rats, suggesting that this parameter is a trait characteristic.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA