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Pregled bibliografske jedinice broj: 381455

Antitumour and Antimalarial Activity of Artemisinin-Acridine Hybrids

Jones, Michael; Mercer, Amy E.; Stocks, Paul A.; La Pensée, Louise J. I.; Cosstick, Rick; Park, B. Kevin; Kennedy, Miriam E.; Piantanida, Ivo; Ward, Stephen A.; Davies, Jill et al.
Antitumour and Antimalarial Activity of Artemisinin-Acridine Hybrids // Bioorganic & medicinal chemistry letters, 19 (2009), 7; 2033-2037 doi:10.1016/j.bmcl.2009.02.028 (međunarodna recenzija, članak, znanstveni)

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Naslov
Antitumour and Antimalarial Activity of Artemisinin-Acridine Hybrids

Autori
Jones, Michael ; Mercer, Amy E. ; Stocks, Paul A. ; La Pensée, Louise J. I. ; Cosstick, Rick ; Park, B. Kevin ; Kennedy, Miriam E. ; Piantanida, Ivo ; Ward, Stephen A. ; Davies, Jill ; Bray, Patrick G. ; Rawe, Sarah L. ; Baird, Jonathan ; Charidza, Tafadzwa ; Janneh, Omar ; Stocks, Paul A. ; O’ Neill, Paul M.

Izvornik
Bioorganic & medicinal chemistry letters (0960-894X) 19 (2009), 7; 2033-2037

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Artemisinin ; acridine ; antimalarial ; anticancer ; apoptosis ; DNA ; confocal microscopy

Sažetak
Artemisinin-acridine hybrids were prepared and evaluated for their in vitro activity against tumour cell lines and a chloroquine sensitive strain of Plasmodium falciparum. They showed a 2 to 4 fold increase in activity against HL60, MDA-MB-231 and MCF-7 cells in comparison with dihydroartemisinin (DHA) and moderate antimalarial activity. Strong evidence that the compounds induce apoptosis in HL60 cells was obtained by flow cytometry, which indicated accumulation of cells in the G1 phase of the cell cycle.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Piantanida, Ivo, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Ivo Piantanida (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com doi.org

Citiraj ovu publikaciju:

Jones, Michael; Mercer, Amy E.; Stocks, Paul A.; La Pensée, Louise J. I.; Cosstick, Rick; Park, B. Kevin; Kennedy, Miriam E.; Piantanida, Ivo; Ward, Stephen A.; Davies, Jill et al.
Antitumour and Antimalarial Activity of Artemisinin-Acridine Hybrids // Bioorganic & medicinal chemistry letters, 19 (2009), 7; 2033-2037 doi:10.1016/j.bmcl.2009.02.028 (međunarodna recenzija, članak, znanstveni)
Jones, M., Mercer, A., Stocks, P., La Pensée, L., Cosstick, R., Park, B., Kennedy, M., Piantanida, I., Ward, S. & Davies, J. (2009) Antitumour and Antimalarial Activity of Artemisinin-Acridine Hybrids. Bioorganic & medicinal chemistry letters, 19 (7), 2033-2037 doi:10.1016/j.bmcl.2009.02.028.
@article{article, author = {Jones, Michael and Mercer, Amy E. and Stocks, Paul A. and La Pens\'{e}e, Louise J. I. and Cosstick, Rick and Park, B. Kevin and Kennedy, Miriam E. and Piantanida, Ivo and Ward, Stephen A. and Davies, Jill and Bray, Patrick G. and Rawe, Sarah L. and Baird, Jonathan and Charidza, Tafadzwa and Janneh, Omar and Stocks, Paul A. and O’ Neill, Paul M.}, year = {2009}, pages = {2033-2037}, DOI = {10.1016/j.bmcl.2009.02.028}, keywords = {Artemisinin, acridine, antimalarial, anticancer, apoptosis, DNA, confocal microscopy}, journal = {Bioorganic and medicinal chemistry letters}, doi = {10.1016/j.bmcl.2009.02.028}, volume = {19}, number = {7}, issn = {0960-894X}, title = {Antitumour and Antimalarial Activity of Artemisinin-Acridine Hybrids}, keyword = {Artemisinin, acridine, antimalarial, anticancer, apoptosis, DNA, confocal microscopy} }
@article{article, author = {Jones, Michael and Mercer, Amy E. and Stocks, Paul A. and La Pens\'{e}e, Louise J. I. and Cosstick, Rick and Park, B. Kevin and Kennedy, Miriam E. and Piantanida, Ivo and Ward, Stephen A. and Davies, Jill and Bray, Patrick G. and Rawe, Sarah L. and Baird, Jonathan and Charidza, Tafadzwa and Janneh, Omar and Stocks, Paul A. and O’ Neill, Paul M.}, year = {2009}, pages = {2033-2037}, DOI = {10.1016/j.bmcl.2009.02.028}, keywords = {Artemisinin, acridine, antimalarial, anticancer, apoptosis, DNA, confocal microscopy}, journal = {Bioorganic and medicinal chemistry letters}, doi = {10.1016/j.bmcl.2009.02.028}, volume = {19}, number = {7}, issn = {0960-894X}, title = {Antitumour and Antimalarial Activity of Artemisinin-Acridine Hybrids}, keyword = {Artemisinin, acridine, antimalarial, anticancer, apoptosis, DNA, confocal microscopy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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