Naslov
Spray-dried chitosan microspheres with lecithin nanocores as cyclosporin A delivery system

Autori
Davosir Klarić, Željka ; Hafner, Anita ; Tomić, Siniša ; Zubčić, Snježana ; Filipović-Grčić, Jelena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Farmacevtski vestnik / Mrhar, Aleš ; Baumgartner, Saša - Ljubljana : Slovenian Pharmaceutical Society, 2008, 115-116

Skup
7th Central Europen Symposium on Pharmaceutical Technology and Biodekivery Systems

Mjesto i datum
Ljubljana, Slovenija, 18.09.2008. - 20.09.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Spray-driying; Chitosan; Microspheres; Lecithin; Cyclosporin A

Sažetak
Cyclosporin is a highly lipophilic neutral cyclic peptide consisting of 11 amino acids. Its low water solubility present a serious problem causing undesirable biopharmaceutical properties, such as erratic bioavailability from oral and topical routes (1). To overcome this problem bioadhesive drug delivery system like chitosan microspheres could be used (2). Chitosan, a polycationic biopolymer is well known for its several favorable biological properties such as biodegradability, nontoxicity and biocompatibility (2). In this study spray-drying method was used for preparing chitosan microspheres with lecithin nanocores as delivery system for cyclosporin A (CyA). The swelling properties of the microspheres and in vitro CyA release were investigated. A new method for the preparation of spray-dried CyA-loaded hydrophilic microspheres was developed. Incorporation of lecithin nanocores into hydrophylic chitosan matrix resulted in improved CyA entrapment, swelling ability and control over CyA release.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA