Naslov
Mixed poloxamer/chitosan systems as nanocarriers for dexamethasone

Autori
Pepić, Ivan ; Lovrić, Jasmina ; Filipović-Grčić, Jelena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Farmacevtski vestnik / Mrhar, Aleš ; Baumgartner, Saša - Ljubljana : Slovenian Pharmaceutical Society, 2008, 79-80

Skup
7th Central Europen Symposium on Pharmaceutical Technology and Biodekivery Systems

Mjesto i datum
Ljubljana, Slovenija, 18.09.2008. - 20.09.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Poloxamer; Chitosan; Nanocarriers; Dexamethasone

Sažetak
Poor ocular bioavailability is the result of the fast elimination of the applied drug and relative impermeability of the corneal epithelial membrane. Drug delivery systems could help to overcome these problems by providing prolonged contact with the eye surface, sustained release of drug and enhanced corneal epithelial permeability. Poloxamers are the block copolymers consisting of poly(oxyethylene) and poly(oxypropylene) units (PEO/PPO/PEO). Due to inherent surface active properties, they were employed as solubilizers and proposed as artificial tears. In addition their possible enhancer effect on drug permeation through cell membranes has been reported. Among other polymeric carriers used, cationic chitosan has attracted considerable attention due to its biocompatibility, biodegradability and ability to enhance paracellular transport of drugs (1-2). Therefore, chitosan seems worthwhile exploring as permeation coenhancer in mixed poloxamer/chitosan colloidal nanosystem. The aim of this study was to investigate the influence of chitosan on the stability, loading capacity and release of dexamethasone (DEX) from mixed poloxamer/chitosan systems. Mixed poloxamer/chitosan systems as nanocarriers for dexamethasone have been successfully prepared. Chitosan inducement in the F127 system did not influence the micelle formation, their size, stability, drug loading and release. However, the systems developed were characterised with positive surface charge originated from chitosan thus showing potential for improved ocular delivery.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

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