Naslov
The association between upper gastrointestinal lesions and high sensitivity C-reactive protein in coronary artery disease patients

Autori
Fabijanić, Damir ; Banić, Marko ; Kardum, Duško ; Sutlić, Željko ; Šimunić, Miroslav ; Bonacin, Damir ; Romić, Željko, Petričušić, Lidija ; Kujundžić, Milan

Izvornik
Medical Science Monitor (1234-1010) 15 (2009), 2; CR45-CR50

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
coronary artery disease; C-reactive protein; upper gastrointestinal lesions

Sažetak
BACKGROUND: Although high sensitivity C-reactive protein (hs-CRP) testing is not specific for coronary atherosclerosis, elevated hs-CRP is recently accepted as an independent predictor of future cardiovascular events. Also, connection between upper gastrointestinal lesions (UGIL) and coronary artery disease (CAD) has been observed. We hypothesized that UGIL increase hs-CRP in CAD patient. METHODS: The 150 patients with stable CAD were enrolled in study. The demographic and clinical variables, and chronic medication using were gathered from a structured questionnaire. UGIL severity was determined by modified Lanza score, H. pylori status was evaluated with histology of the gastric mucosa, and severity of CAD was determined by modified Gensini score. Independent correlation between hs-CRP and UGIL was tested by logistic regression analysis. RESULTS: The overall hs-CRP value was higher in patients with UGIL than in the patients with normal endoscopy (8.14&#177; ; ; 4.53 mg/L vs. 4.64&#177; ; ; 3.06 mg/L, P<0.0001). hs-CRP value positively correlated with UGIL severity (r=0.434, P<0.0001). Correlation between UGIL and hs-CRP value remained significant after adjustment for coronary risk factors, medication used, CAD severity and H. pylori status (Standardized coefficient &#946; =1.272, P<0.0001). However, when hs-CRP was used as categorical variable multivariate analysis revealed independent correlation between UGIL and hs-CRP value categories only >6.1 mg/L CONCLUSIONS: The elevated levels of hs-CRP may be predictive for UGIL, thus endoscopy should be considered in CAD patients with elevated hs-CRP even with no dyspeptic symptoms. Because CRP plays an active role in atherothrombosis, UGIL with subsequent elevated CRP levels could increase cardiovascular risk in those patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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