Naslov
Toll-like receptors in respiratory syncytial virus infection.

Autori
Bendelja, Krešo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
"Balkan Flow Users' Meeting"

Mjesto i datum
Rovinj, Hrvatska, 26.09.2008. - 01.10.2008

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
Toll-like receprors; RSV infection

Sažetak
Toll-like receptor (TLR) family of transmembrane proteins are pattern recognition receptors for common pathogen molecular motives. Upon pathogen challenge, TLRs enable innate immune mechanisms to inactivate, or at least sustain pathogen spread until the initiation of adaptive immune response. Moreover, TLR engagement in monocytes and dendritic cells initiate and support immune reaction cascade resulting in development of specific immunity. Respiratory syncytial virus (RSV) infection is the most common respiratory infection up to 2 years of age. Although usually results in mild disease, in some infants RSV causes severe lower respiratory tract inflammation presented with bronchiolitis. A number of studies so far stressed out immature immune system as possible cause. We examined TLR expression of different peripheral blood leukocyte populations in newborns and infants with RSV bronchiolitis both in acute and convalescent phase, as well as in healthy controls, in order to evaluate innate immune response during the disease.

Izvorni jezik
Engleski

POVEZANOST RADA