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Pregled bibliografske jedinice broj: 38003

Changes of autoantibodies against oxidatively modified low density lipoproteines during long-term LDL-apheresis


Turk, Zdenka; Mrzljak, Vladimir; Turk, Nikša; Metelko, Željko
Changes of autoantibodies against oxidatively modified low density lipoproteines during long-term LDL-apheresis // Diabetes, nutrition and metabolism : clinical and experimantal, 12 (1999), 6; 413-417 (međunarodna recenzija, članak, znanstveni)


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Naslov
Changes of autoantibodies against oxidatively modified low density lipoproteines during long-term LDL-apheresis

Autori
Turk, Zdenka ; Mrzljak, Vladimir ; Turk, Nikša ; Metelko, Željko

Izvornik
Diabetes, nutrition and metabolism : clinical and experimantal (0394-3402) 12 (1999), 6; 413-417

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
hyperlipidemia; LDL-apheresis; antibodies to oxidized-LDL

Sažetak
The oxidation of low-density lipoproteins (LDL) is considered a key event in the initiation of atherosclerosis. The aim of this study was to follow-up the biological marker of in vivo LDL oxidation (oxidatively modified LDL autoantibody titers) during long-term LDL-apheresis treatment. A patient suffering from severe combined hyperlipidemia underwent LDL-apheresis biweekly and was followed for two years. The significant reduction of baseline total cholesterol (58%), total triglycerides (80%), LDL cholesterol (48%), apoprotein B (50%) and apolipoprotein (a) (61%) may be considered as a good response to the treatment. The titer of autoantibodies (IgG) against oxidatively modified LDL (malondialdehyde-derived LDL) was followed throughout the study and showed dynamic changes. The measured values were multiple compared as means?SD over each semester of apheresis application: I semester 70.0?8.3 U/ml, n=12 ; II semester 58.0?13.8 U/ml, n=12 ; III semester 37.6?6.0 U/ml, n=12 ; IV semester 34.3?7.0 U/ml, n=12 ; ANOVA: I vs II semester p<0.083, II vs III semester p<0.00053, III vs IV semester p<0.248. In parallel to the changes in this biochemical parameter, regression of numerous xanthomas was clinically observed. In spite of this, the presence of ox-LDL antibodies was enhanced in comparison to antibody titer detected in a group of age-matched normolipemic healthy controls (n=15 ; 19.4?8.6 ; p<0.01). Classical lipoprotein parameters were correlated with the titer of autoantibodies against oxLDL and showed low correlation coefficients: total cholesterol vs oxLDLab, r=0.36 ; triglycerides vs oxLDLab, r=0.43 ; LDL-cholesterol vs oxLDLab, r=0.14 ; HDL-cholesterol vs oxLDLab, r=-0.33 ; apo B vs oxLDLab, r=0.25 ; apo (a) vs oxLDLab, r=-0.05. Our study showed an additional benefit of LDL-apheresis therapy. The production of autoantibodies against oxidized-LDL was reduced during the treatment, indicating a lower level of the atherogenic antigen.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
045003

Ustanove:
Klinika za dijabetes, endokrinologiju i bolesti metabolizma Vuk Vrhovac

Profili:

Avatar Url Vladimir Mrzljak (autor)

Avatar Url Željko Metelko (autor)

Avatar Url Zdenka Turk (autor)

Avatar Url Nikša Turk (autor)


Citiraj ovu publikaciju:

Turk, Zdenka; Mrzljak, Vladimir; Turk, Nikša; Metelko, Željko
Changes of autoantibodies against oxidatively modified low density lipoproteines during long-term LDL-apheresis // Diabetes, nutrition and metabolism : clinical and experimantal, 12 (1999), 6; 413-417 (međunarodna recenzija, članak, znanstveni)
Turk, Z., Mrzljak, V., Turk, N. & Metelko, Ž. (1999) Changes of autoantibodies against oxidatively modified low density lipoproteines during long-term LDL-apheresis. Diabetes, nutrition and metabolism : clinical and experimantal, 12 (6), 413-417.
@article{article, author = {Turk, Zdenka and Mrzljak, Vladimir and Turk, Nik\v{s}a and Metelko, \v{Z}eljko}, year = {1999}, pages = {413-417}, keywords = {hyperlipidemia, LDL-apheresis, antibodies to oxidized-LDL}, journal = {Diabetes, nutrition and metabolism : clinical and experimantal}, volume = {12}, number = {6}, issn = {0394-3402}, title = {Changes of autoantibodies against oxidatively modified low density lipoproteines during long-term LDL-apheresis}, keyword = {hyperlipidemia, LDL-apheresis, antibodies to oxidized-LDL} }
@article{article, author = {Turk, Zdenka and Mrzljak, Vladimir and Turk, Nik\v{s}a and Metelko, \v{Z}eljko}, year = {1999}, pages = {413-417}, keywords = {hyperlipidemia, LDL-apheresis, antibodies to oxidized-LDL}, journal = {Diabetes, nutrition and metabolism : clinical and experimantal}, volume = {12}, number = {6}, issn = {0394-3402}, title = {Changes of autoantibodies against oxidatively modified low density lipoproteines during long-term LDL-apheresis}, keyword = {hyperlipidemia, LDL-apheresis, antibodies to oxidized-LDL} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka::


  • Chemical Abstracts
  • Excerpta Medica
  • Index Medicus
  • MEDLINE
  • Diabetes Contents





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