Naslov
4-hydroxynonenal as a second messenger of free radicals and growth modifying factor

Autori
Žarković, Neven ; Žarković, Kamelija ; Schaur, Rudolf Joerg ; Štolc, Svorad ; Schlag, Gunther ; Redl, Heinz ; Waeg, Georg ; Borović, Suzana ; Lončarić, Iva ; Jurić, Gordana ; Hlavka, Vladimir

Izvornik
Life Sciences (0024-3205) 65 (1999), 18-19; 1901-1904

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
oxidative stress; lipid peroxidation; 4-hydroxynonenal; brain; c-fos; immunohistochemistry; cell growth; free radicals; reactive oxygen species

Sažetak
Immunohistochemical analysis of the distribution of the lipid peroxidation product 4-hydroxynonenal (HNE) in the brain of baboons exposed to experimental hemorrhagic traumatic shock or sepsis showed that systemic oxidative stress and the thereby generated HNE affect the blood:brain barrier and the regulation of cerebral blood flow determing secondary brain damage. Similarly, HNE was determined during ischemia in the brain blood vessels of rats exposed to ischemia/reperfusion injury of the brain. After reperfusion, HNE disappeared from the blood vessels but remained in neurones and in glial cells. Since HNE modulates cell proliferation and differentiation (including proto-oncogene expression), it is postulated that HNE might have prominent local and systemic effects that are not only harmful but beneficial, too, determing the outcome of various pathophysiological conditions based on oxidative stress.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti

POVEZANOST RADA